ScienceDaily (July 12, 2010) — Lowly bacteria are turning out to be much more complex than previously thought.
This discovery that protein acetylation is common in bacteria has led to the "dawning of a new age" in bacterial research, senior author Alan Wolfe, PhD. and colleagues wrote.
Protein acetylation is a molecular reaction inside the cell. It modifies and thus affects the function of proteins, including the molecular machinery responsible for turning genes on or off.
Bacteria make up one of the three domains of life. The other two domains are archaea (single-cell organisms distinct from bacteria) and eukaryotes (which include plants and animals). Bacteria evolved before eukaryotes, but they are not as primitive as once thought.
"Bacteria have long been considered simple relatives of eukaryotes," Wolfe and colleagues wrote. "Obviously, this misperception must be modified."
For example, protein acetylation historically had been considered mostly a eukaryotic phenomenon. But recent research indicates that acetylation also has a broad impact on bacterial physiology.
"There is a whole process going on that we have been blind to," Wolfe said.
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Read more here/Leia mais aqui: Science Daily
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Published Online: 12 May 2010
Bacterial protein acetylation: the dawning of a new age
Linda I. Hu, Bruno P. Lima and Alan J. Wolfe*
Department of Microbiology and Immunology, Loyola University Chicago, Stritch School of Medicine, 2160 S. First Avenue, Building 105, Maywood, IL 60153, USA.
Correspondence to *E-mail awolfe@lumc.edu; Tel. (+1) 708 216 5814; Fax (+1) 708 216 9574.
ABSTRACT
Protein acetylation has historically been considered a predominantly eukaryotic phenomenon. Recent evidence, however, supports the hypothesis that acetylation broadly impacts bacterial physiology. To explore more rapidly the impact of protein acetylation in bacteria, microbiologists can benefit from the strong foundation established by investigators of protein acetylation in eukaryotes. To help advance this learning process, we will summarize the current understanding of protein acetylation in eukaryotes, discuss the emerging link between acetylation and metabolism and highlight the best-studied examples of protein acetylation in bacteria.
Accepted 1 May, 2010.
DIGITAL OBJECT IDENTIFIER (DOI)10.1111/j.1365-2958.2010.07204.x
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