Detectando a mistura e calculando os parâmetros demográficos de múltiplas populações humanas antigas

MBE Advance Access published online on May 6, 2009
Molecular Biology and Evolution, doi:10.1093/molbev/msp096

Research Article

Detecting ancient admixture and estimating demographic parameters in multiple human populations

Jeffrey D. Wall1,*, Kirk E. Lohmueller2 and Vincent Plagnol3

1 Institute for Human Genetics and Department of Epidemiology and Biostatistics, University of California San Francisco, San Francisco, CA

2 Department of Molecular Biology and Genetics and Department of Biological Statistics and Computational Biology, Cornell University, Ithaca, NY

3 Juvenile Diabetes Research Foundation/Wellcome Trust Diabetes and Inflammation Laboratory, University of Cambridge, Cambridge, United Kingdom

* Address for correspondence: Jeff Wall, Institute for Human Genetics, UCSF, 513 Parnassus Ave., S965, San Francisco, CA 94143, Phone: 415-476-4063, Email: wallj@humgen.ucsf.edu

Received for publication October 30, 2008. Revision received March 7, 2009. Accepted for publication April 18, 2009.

Abstract:

We analyze patterns of genetic variation in extant human polymorphism data from the NIEHS SNPs project to estimate human demographic parameters. We update our previous work by considering a larger data set (more genes and more populations), and by explicitly estimating the amount of putative admixture between modern humans and archaic human groups (e.g., Neandertals, Homo erectus, H. floresiensis). We find evidence for this ancient admixture in European, East Asian and West African samples, suggesting that admixture between diverged hominin groups may be a general feature of recent human evolution.

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