Tobias Bollenbach1, Kalin Vetsigian1, and Roy Kishony1,2,3
-Author Affiliations
1 Department of Systems Biology, Harvard Medical School, Boston, Massachusetts 02115, USA;
2 School of Engineering and Applied Sciences, Harvard University, Cambridge, Massachusetts 02138, USA
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The discovery of the genetic code was one of the most important advances of modern biology. But there is more to a DNA code than protein sequence; DNA carries signals for splicing, localization, folding, and regulation that are often embedded within the protein-coding sequence. In this issue, Itzkovitz and Alon show that the specific 64-to-20 mapping found in the genetic code may have been optimized for permitting protein-coding regions to carry this extra information and suggest that this property may have evolved as a side benefit of selection to minimize the negative effects of frameshift errors.
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