Implicações éticas do uso de métodos cobrindo todo o genoma em pesquisa médica

quinta-feira, março 18, 2010

European Journal of Human Genetics (2010) 18, 398–403; doi:10.1038/ejhg.2009.191; published online 4 November 2009

Ethical implications of the use of whole genome methods in medical research

EJHGOpen

Jane Kaye1, Paula Boddington1, Jantina de Vries1, Naomi Hawkins1 and Karen Melham1

1Department of Public Health, Ethox Centre, University of Oxford, Headington, Oxford, UK

Correspondence: Dr J Kaye, Department of Public Health, Ethox Centre, University of Oxford, DPHPC, Old Road Campus, Headington, Oxford, Oxon OX3 7LF, UK. Tel: +44 1865 287 898; Fax: +44 1865 226 938; E-mail: jane.kaye@ethox.ox.ac.uk

Abstract

The use of genome-wide association studies (GWAS) in medical research and the increased ability to share data give a new twist to some of the perennial ethical issues associated with genomic research. GWAS create particular challenges because they produce fine, detailed, genotype information at high resolution, and the results of more focused studies can potentially be used to determine genetic variation for a wide range of conditions and traits. The information from a GWA scan is derived from DNA that is a powerful personal identifier, and can provide information not just on the individual, but also on the individual's relatives, related groups, and populations. Furthermore, it creates large amounts of individual-specific digital information that is easy to share across international borders. This paper provides an overview of some of the key ethical issues around GWAS: consent, feedback of results, privacy, and the governance of research. Many of the questions that lie ahead of us in terms of the next generation sequencing methods will have been foreshadowed by GWAS and the debates around ethical and policy issues that these have created.

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