Morfologia canina: caçando genes e rastreando mutações

terça-feira, março 30, 2010

Canine Morphology: Hunting for Genes and Tracking Mutations

Abigail L. Shearin1,2, Elaine A. Ostrander1*

1 National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland, United States of America, 2 University of Pennsylvania School of Veterinary Medicine, Philadelphia, Pennsylvania, United States of America

Citation: Shearin AL, Ostrander EA (2010) Canine Morphology: Hunting for Genes and Tracking Mutations. PLoS Biol 8(3): e1000310. doi:10.1371/journal.pbio.1000310

Published: March 2, 2010

This is an open-access article distributed under the terms of the Creative Commons Public Domain declaration which stipulates that, once placed in the public domain, this work may be freely reproduced, distributed, transmitted, modified, built upon, or otherwise used by anyone for any lawful purpose.

Funding: This work is supported by the intramural Program of the National Human Genome Research Institute and the Howard Hughes Scholars Program. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.

Competing interests: The authors have declared that no competing interests exist.

Abbreviations: AKC, American Kennel Club; GWAS, genome-wide association study; FGF4, fibroblast growth factor-4; FGF5, fibroblast growth factor-5; IGF-1, insulin like growth factor-1; KRT71, keratin71; LD, linkage disequilibrium; Mc1r, melanocortin 1 receptor; PWD, Portuguese Water Dog; RSPO2, R-spondin-2; SINE, short-interspersed nuclear element; SNP, single nucleotide polymorphism; SSR, simple sequence repeat

* E-mail: eostrand@mail.nih.gov

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