Organization of Transcription
Lyubomira Chakalova1,2 and Peter Fraser1
-Author Affiliations
1Laboratory of Chromatin and Gene Expression, The Babraham Institute, Babraham Research Campus, Cambridge, CB22 3AT, United Kingdom
2Research Centre for Genetic Engineering and Biotechnology, Macedonian Academy of Sciences and Arts, Skopje 1000, Republic of Macedonia
Correspondence: peter.fraser@bbsrc.ac.uk
Abstract
Investigations into the organization of transcription have their origins in cell biology. Early studies characterized nascent transcription in relation to discernable nuclear structures and components. Advances in light microscopy, immunofluorescence, and in situ hybridization helped to begin the difficult task of naming the countless individual players and components of transcription and placing them in context. With the completion of mammalian genome sequences, the seemingly boundless task of understanding transcription of the genome became finite and began a new period of rapid advance. Here we focus on the organization of transcription in mammals drawing upon information from lower organisms where necessary. The emerging picture is one of a highly organized nucleus with specific conformations of the genome adapted for tissue-specific programs of transcription and gene expression.
Copyright © 2010 Cold Spring Harbor Laboratory Press; all rights reserved
+++++
+++++
