Public release date: 28-Sep-2010
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New book reviews ancient and modern worlds of RNA
COLD SPRING HARBOR, N.Y. (Sept. 28, 2010) -- A new book, RNA Worlds: From Life's Origins to Diversity in Gene Regulation, reviews our understanding of two RNA worlds: the primordial RNA world before DNA, in which RNA was both information store and biocatalyst; and the contemporary RNA world, in which mRNA, tRNA, rRNA, siRNA, miRNA, and a host of other RNAs operate.
"[T]he plasticity of RNA stemming from its 2' hydroxyl group and single-stranded nature, which permits diverse folding in contrast to its storage molecule cousin, DNA, continues to fascinate," write the editors, John F. Atkins, Raymond F. Gesteland, and Thomas R. Cech, in the book's preface.
Once thought to be just a messenger that allows genetic information encoded in DNA to direct the formation of proteins, RNA is now known to be a highly versatile molecule that has multiple roles in cells. It can function as an enzyme, scaffold various subcellular structures, and regulate gene expression through a variety of mechanisms, as well as act as a key component of the protein synthesis and splicing machinery. Perhaps most interestingly, increasing evidence indicates that RNA preceded DNA as the hereditary material and played a crucial role in the early evolution of life on Earth.
Once thought to be just a messenger that allows genetic information encoded in DNA to direct the formation of proteins, RNA is now known to be a highly versatile molecule that has multiple roles in cells. It can function as an enzyme, scaffold various subcellular structures, and regulate gene expression through a variety of mechanisms, as well as act as a key component of the protein synthesis and splicing machinery. Perhaps most interestingly, increasing evidence indicates that RNA preceded DNA as the hereditary material and played a crucial role in the early evolution of life on Earth.
The early chapters of the book analyze the role of RNA in the first life forms and the appearance of cells. Subsequent chapters examine riboswitches and ribozymes, establishing what the RNA molecule is capable of alone. The book goes on to discuss the evolution of ribosomes and the functions of RNPs, before reviewing the recent work that has revolutionized our understanding of gene regulation by non-coding RNAs, including miRNAs and siRNAs. Also covered are viral RNAs, telomerase RNA, and tools for scientists who work on RNA. Each chapter is written by one or more experts in the field.
The book has just been released by Cold Spring Harbor Laboratory Press, and is essential reading for all molecular biologists and biochemists, as well as chemists interested in RNA technology, information storage, or enzyme catalysis.
About the book: RNA Worlds: From Life's Origins to Diversity in Gene Regulation (ISBN 978-0-879699-46-8; © 2011 Cold Spring Harbor Laboratory Press) was edited by John F. Atkins (University of Utah, University College Cork, and Trinity College Dublin), Raymond F. Gesteland (University of Utah), and Thomas R. Cech (Howard Hughes Medical Institute and University of Colorado). It is hardcover and is 361 pp. in length (8 1/2" × 10 7/8"; illus., index). For more information,
About Cold Spring Harbor Laboratory Press: Cold Spring Harbor Laboratory Press is an internationally renowned publisher of books, journals, and electronic media, located on Long Island, New York. Since 1933, it has furthered the advance and spread of scientific knowledge in all areas of genetics and molecular biology, including cancer biology, plant science, bioinformatics, and neurobiology. It is a division of Cold Spring Harbor Laboratory, an innovator in life science research and the education of scientists, students, and the public. For more information, visit www.cshlpress.com.
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