Conservação evolucionária de mecanismos para a regionalização, proliferação e interconexão neural no desenvolvimento do cérebro

quinta-feira, novembro 26, 2009

Evolutionary conservation of mechanisms for neural regionalization, proliferation and interconnection in brain development

Heinrich Reichert*

- Author Affiliations

Biozentrum, University of Basel 4056 Basel, Switzerland


Comparative studies of brain development in vertebrate and invertebrate model systems demonstrate remarkable similarities in expression and action of developmental control genes during embryonic patterning, neural proliferation and circuit formation in the brain. Thus, comparable sets of developmental control genes are involved in specifying the early brain primordium as well as in regionalized patterning along its anteroposterior and dorsoventral axes. Furthermore, similar cellular and molecular mechanisms underlie the formation and proliferation of neural stem cell-like progenitors that generate the neurons in the central nervous systems. Finally, neural identity and some complex circuit interconnections in specific brain domains appear to be comparable in vertebrates and invertebrates and may depend on similar developmental control genes.

brain development pattern formation proliferation neural circuitry


One contribution of 10 to a Special Feature on ‘Brain evolution’.

Received June 24, 2008.

Accepted July 28, 2008.
© 2008 The Royal Society