The DNA Damage Response: Ten Years After
J. Wade Harper1, , and Stephen J. Elledge2, 3, 4, ,
1 Department of Pathology, Harvard Medical School, Boston, MA 02115, USA
2 Howard Hughes Medical Institute, Boston, MA 02115, USA
3 Department of Genetics, Harvard Medical School, Boston, MA 02115, USA
4 Center for Genetics and Genomics, Brigham and Women's Hospital, Boston, MA 02115, USA
Corresponding author
Corresponding author
Summary
The DNA damage response (DDR), through the action of sensors, transducers, and effectors, orchestrates the appropriate repair of DNA damage and resolution of DNA replication problems, coordinating these processes with ongoing cellular physiology. In the past decade, we have witnessed an explosion in understanding of DNA damage sensing, signaling, and the complex interplay between protein phosphorylation and the ubiquitin pathway employed by the DDR network to execute the response to DNA damage. These findings have important implications for aging and cancer.
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