Point-of-View
Pseudogenes are not pseudo any more
RNA Biology
Volume 9, Issue 1 January 2012
Pages 27 - 32
http://dx.doi.org/10.4161/rna.9.1.18277
Keywords: RNA regulation, biological function, pseudogene, transcription
Authors: Yan-Zi Wen, Ling-Ling Zheng, Liang-Hu Qu, Francisco J Ayala and Zhao-Rong Lun
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Abstract:
Recent significant progress toward understanding the function of pseudogenes in protozoa (Trypanosoma brucei), metazoa (mouse) and plants, make it pertinent to provide a brief overview on what has been learned about this fascinating subject. We discuss the regulatory mechanisms of pseudogenes at the post-transcriptional level and advance new ideas toward understanding the evolution of these, sometimes called “garbage genes” or “junk DNA,” seeking to stimulate the interest of scientists and additional research on the subject. We hope this point-of-view can be helpful to scientists working or seeking to work on these and related issues.
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