The EMBO Journal (2011) 30, 1885 - 1895
doi:10.1038/emboj.2011.135
Published online: 28 April 2011
Subject Category:
Chromatin and Transcription
Chromatin: constructing the big picture
Bas van Steensel1
Division of Gene Regulation, Netherlands Cancer Institute, Amsterdam, The Netherlands
Correspondence to:
Bas van Steensel, Division of Gene Regulation, Netherlands Cancer Institute, Plesmanlaan 121, Amsterdam 1066 CX, The Netherlands. Tel.: +31 20 512 2040; Fax: +31 20 512 1989; E-mail: b.v.steensel@nki.nl
Received 10 February 2011; Accepted 6 April 2011
Abstract
Chromatin is the ensemble of genomic DNA and a large number of proteins. Various genome-wide mapping techniques have begun to reveal that, despite the tremendous complexity, chromatin organization is governed by simple principles. This review discusses the principles that drive the spatial architecture of chromatin, as well as genome-wide-binding patterns of chromatin proteins.
Keywords: chromatin; genomes; transcription
+++++
