Origem e evolução dos cromossomos Y em Drosophila

Trends in Genetics, Volume 25, Issue 6, 270-277, 13 May 2009

doi:10.1016/j.tig.2009.04.002

Origin and evolution of Y chromosomes: Drosophila tales

A. Bernardo Carvalho1,,Leonardo B. Koerich1andAndrew G. Clark2

1 Departamento de Genética, Universidade Federal do Rio de Janeiro, Caixa Postal 68011, CEP 21944-970, Rio de Janeiro, Brazil

2 Department of Molecular Biology and Genetics, Cornell University, Ithaca, NY 14853, USA


Abstract

Classically, Y chromosomes are thought to originate from X chromosomes through a process of degeneration and gene loss. Now, the availability of 12 Drosophila genomes provides an opportunity to study the origin and evolution of Y chromosomes in an informative phylogenetic context. Surprisingly, the majority of Drosophila Y-linked genes are recent acquisitions from autosomes and Y chromosome gene gains are more frequent than gene losses. Moreover, the Drosophila pseudoobscura Y chromosome lacks homology with the Y of most Drosophila species. Thus, the Drosophila Y has a different evolutionary history from canonical Y chromosomes (such as the mammalian Y) and it also might have a different origin.

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