Systems biology in biochemical research
Katrin Hübner, Sven Sahle, Ursula Kummer
DOI: 10.1111/j.1742-4658.2011.08217.x
FEBS Jun 2011
Journal compilation © 2011 Federation of European Biochemical Societies
Keywords: systems biology; modeling; simulation
Abstract
Systems biology has received an ever increasing interest during the last decade. A lot of third party funding is spent on this topic which involves quantitative experimentation integrated with computational modeling. Industrial companies are also starting to use this approach more and more often, especially in pharmaceutical research and biotechnology. This leads to the question if all this interest is wisely invested and if there are success stories to be told, for basic science and/or technology/biomedicine. In this review we focus on applications of systems biology approaches that have been employed to shed light on biochemical functions and mechanisms unknown before. We point out which computational and experimental methods are employed most frequently and which trends in systems biology research can be observed. Finally, we discuss some problems that we encountered in publications in the field.
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See here/Vide aqui
