Uma aula de jornalismo científico sobre a complexidade encontrada em levedura

quinta-feira, abril 21, 2011

A Two-Step Process Gets mRNA Loaded and Ready to Go

Richard Robinson*

Freelance Science Writer, Sherborn, Massachusetts, United States of America

Citation: Robinson R (2011) A Two-Step Process Gets mRNA Loaded and Ready to Go. PLoS Biol 9(4): e1001047. doi:10.1371/journal.pbio.1001047

Published: April 19, 2011

Copyright: © 2011 Richard Robinson. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Competing interests: The author has declared that no competing interests exist.


Proteins are the workhorses of the cell, but to get the most work out of them, they need to be in the right place. In neurons, for example, proteins needed at axons differ from those needed at dendrites, while in budding yeast cells, the daughter cell needs proteins the mother cell does not. In each case, one strategy for making sure a protein gets where it belongs is to shuttle its messenger RNA to the right spot before translating it.

The destination for such an mRNA is encoded in a set of so-called “zipcode” elements, which loop out of the RNA string to link up with RNA-binding proteins. In yeast, these proteins join up with a myosin motor that taxis the complex to the encoded location. While this general picture has become clear in the past several years, details of the transport complex itself have remained murky. In this issue of PLoS Biology, Marisa Müller, Dierk Niessing, and colleagues show that the complex forms in stages, with the final protein added only in the cytoplasm, an event crucial to ensuring the transport complex doesn't pick up passengers who weren't meant to travel.

The authors began by showing that a known zipcode element binding protein, called She2p, bound in a similar way to RNAs without the elements as to those with them, suggesting that the job of keeping non-transported RNAs out of the transport complex fell to another protein. Tests of another known complex protein, called Puf6p, were negative, leading the authors to look elsewhere.

...

+++++

FREE PDF GRATIS [OPEN ACCESS]

+++++

NOTA DESTE BLOGGER:

Gente, processos extremamente complexos encontrados em levedura!!! A atual teoria da evolução - a Síntese Evolutiva Moderna não explica esse fato, Fato, FATO da evolução desses processos inteligentes [eu não pude resistir] tipo zip-codes [os nossos CEPs - Código de Endereçamento Postal].

E ainda têm a cara de pau de dizer que a teoria do Design Inteligente é pseudociência. E eu pergunto: pseudociência quem caras-pálidas???