Cell, Volume 140, Issue 4, 460-476, 19 February 2010
Tuomas Tammela1 and Kari Alitalo1, ,
1 Molecular/Cancer Biology Laboratory and Haartman Institute, Biomedicum Helsinki, P.O.B. 63 (Haartmaninkatu 8), 00014 University of Helsinki, Finland
Corresponding author
Summary
The growth of lymphatic vessels (lymphangiogenesis) is actively involved in a number of pathological processes including tissue inflammation and tumor dissemination but is insufficient in patients suffering from lymphedema, a debilitating condition characterized by chronic tissue edema and impaired immunity. The recent explosion of knowledge on the molecular mechanisms governing lymphangiogenesis provides new possibilities to treat these diseases.
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