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An EMBO Journal special on cellular logistics - moving
This Focus issue comprises eight reviews united by a common interest in understanding how and why cells move cargo around. Active transport mechanisms transcend compartment boundaries within cells and permit communication between them. Recent technological advances have opened our eyes to the dynamic nature of such trafficking processes. The examples discussed here by leaders in the field showcase the diversity in transport systems and cargoes, and the complexity of organising these in space and time. Nevertheless, recurrent themes emerge, highlighting universal principles required to coordinate the remarkable logistics of cellular transport.
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Editorial
The five ‘W’s of transport FREE
The EMBO Journal (2011), 30, 3455 - 3456,doi:10.1038/emboj.2011.275
Focus Reviews
Ran-dependent nuclear export mediators: a structural perspective FREE
Diverse import and export complexes mediate transport between the nucleus and cytoplasm. The contribution of structural data to our understanding of the molecular basis underlying specificity and directionality of transport is discussed here.
The EMBO Journal (2011), 30 , 3457 - 3474 , doi:10.1038/emboj.2011.287
Protein export at the ER: loading big collagens into COPII carriers FREE
The secretory pathway needs to accommodate many different types and sizes of cargo. As detailed in this review, the molecules and mechanisms that package large cargoes such as collagen for ER exit have recently been uncovered.
The EMBO Journal (2011), 30, 3475 - 3480,doi:10.1038/emboj.2011.255
Endosome maturation FREE
Many intracellular trafficking events involve endosomes as key sorting hubs. This review considers the processes that drive the maturation of this highly dynamic and versatile organelle.The EMBO Journal (2011), 30, 3481 - 3500,doi:10.1038/emboj.2011.286Let's go bananas: revisiting the endocytic BAR code FREE
Vesicle formation is accompanied by dramatic changeds in membrane geometry. The role of the BAR domain proteins in membrane shaping—with a focus on how their structural features are optimized for this function—is explained here.The EMBO Journal (2011), 30, 3501 - 3515,doi:10.1038/emboj.2011.266Regulation of developmental intercellular signalling by intracellular trafficking FREE
Metazoan development requires the tight spatio-temporal regulation of intercellular signaling. As reviewed here, this involves multi-layered control of the subcellular localization and trafficking of signal pathway components.The EMBO Journal (2011), 30, 3516 - 3526,doi:10.1038/emboj.2011.269Coupling viruses to dynein and kinesin-1 FREE
This review discusses how viruses co-opt the microtubule-based transport systems of their host for intracellular trafficking, and highlights the insights viruses have provided into basic mechanisms of cellular bidirectional cargo transport by microtubule motors.The EMBO Journal (2011), 30, 3527 - 3539,doi:10.1038/emboj.2011.283Published online: 31 August 2011- In this review, our understanding of the mechanisms and regulation of dendritic mRNA localization is synthesized into a ‘sushi belt’ model of mRNA transport and translational control in neurons.The EMBO Journal (2011), 30, 3540 - 3552,doi:10.1038/emboj.2011.278
Intercellular and systemic movement of RNA silencing signalsFREE
Local small RNA generation can silence gene expression over long distances. Recent progress in our understanding of how these mobile RNA species are transported between cells is described.The EMBO Journal (2011), 30, 3553 - 3563,doi:10.1038/emboj.2011.274
