Miniature Human Livers Created in the Lab
ScienceDaily (Oct. 31, 2010) — Researchers at the Institute for Regenerative Medicine at Wake Forest University Baptist Medical Center have reached an early, but important, milestone in the quest to grow replacement livers in the lab. They are the first to use human liver cells to successfully engineer miniature livers that function -- at least in a laboratory setting -- like human livers. The next step is to see if the livers will continue to function after transplantation in an animal model.
An early milestone in the quest to grow replacement livers in the lab has been achieved. Researchers have used human liver cells to successfully engineer miniature livers that function -- at least in a laboratory setting -- like human livers. (Credit: iStockphoto/Sebastian Kaulitzki)
The ultimate goal of the research, which will be presented on October 31 at the annual meeting of the American Association for the Study of Liver Diseases in Boston, is to provide a solution to the shortage of donor livers available for patients who need transplants. Laboratory-engineered livers could also be used to test the safety of new drugs.
"We are excited about the possibilities this research represents, but must stress that we're at an early stage and many technical hurdles must be overcome before it could benefit patients," said Shay Soker, Ph.D., professor of regenerative medicine and project director. "Not only must we learn how to grow billions of liver cells at one time in order to engineer livers large enough for patients, but we must determine whether these organs are safe to use in patients."
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