Regulation of Recombination and Genomic Maintenance
Wolf-Dietrich Heyer1,2
1Department of Microbiology and Molecular Genetics, University of California, Davis, Davis, California 95616-8665
2Department of Molecular and Cellular Biology, University of California, Davis, Davis, California 95616-8665
Correspondence: wdheyer{at}ucdavis.edu
Abstract
Recombination is a central process to stably maintain and transmit a genome through somatic cell divisions and to new generations. Hence, recombination needs to be coordinated with other events occurring on the DNA template, such as DNA replication, transcription, and the specialized chromosomal functions at centromeres and telomeres. Moreover, regulation with respect to the cell-cycle stage is required as much as spatiotemporal coordination within the nuclear volume. These regulatory mechanisms impinge on the DNA substrate through modifications of the chromatin and directly on recombination proteins through a myriad of posttranslational modifications (PTMs) and additional mechanisms. Although recombination is primarily appreciated to maintain genomic stability, the process also contributes to gross chromosomal arrangements and copy-number changes. Hence, the recombination process itself requires quality control to ensure high fidelity and avoid genomic instability. Evidently, recombination and its regulatory processes have significant impact on human disease, specifically cancer and, possibly, neurodegenerative diseases.
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Pergunta deste blogger:
A regulação da recombinação e manutenção genômica: mero acaso, fortuita necessidade ou design inteligente???
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Pergunta deste blogger:
A regulação da recombinação e manutenção genômica: mero acaso, fortuita necessidade ou design inteligente???
