Origem da vida: A fosforilação, oligomerização e auto-montagem em água sob condições prebióticas potenciais

segunda-feira, dezembro 04, 2017

Phosphorylation, oligomerization and self-assembly in water under potential prebiotic conditions

Clémentine Gibard, Subhendu Bhowmik, Megha Karki, Eun-Kyong Kim & Ramanarayanan Krishnamurthy

Nature Chemistry


Download Citation

Chemical biology Organic chemistry Chemical origin of life

Received: 14 April 2017 Accepted: 22 September 2017

Published online: 06 November 2017

Source/Fonte: Nature


Prebiotic phosphorylation of (pre)biological substrates under aqueous conditions is a critical step in the origins of life. Previous investigations have had limited success and/or require unique environments that are incompatible with subsequent generation of the corresponding oligomers or higher-order structures. Here, we demonstrate that diamidophosphate (DAP)—a plausible prebiotic agent produced from trimetaphosphate—efficiently (amido)phosphorylates a wide variety of (pre)biological building blocks (nucleosides/tides, amino acids and lipid precursors) under aqueous (solution/paste) conditions, without the need for a condensing agent. Significantly, higher-order structures (oligonucleotides, peptides and liposomes) are formed under the same phosphorylation reaction conditions. This plausible prebiotic phosphorylation process under similar reaction conditions could enable the systems chemistry of the three classes of (pre)biologically relevant molecules and their oligomers, in a single-pot aqueous environment.


Subscription or payment needed/Requer assinatura ou pagamento