Membranes are functionalized by a proteolipid code
Troy A. Kervin & Michael Overduin
BMC Biology volume 22, Article number: 46 (2024)
Abstract
Membranes are protein and lipid structures that surround cells and other biological compartments. We present a conceptual model wherein all membranes are organized into structural and functional zones. The assembly of zones such as receptor clusters, protein-coated pits, lamellipodia, cell junctions, and membrane fusion sites is explained to occur through a protein-lipid code. This challenges the theory that lipids sort proteins after forming stable membrane subregions independently of proteins.
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