Between form and function: the complexity of genome folding
A. Marieke Oudelaar Lars L.P. Hanssen Ross C. Hardison Mira T. Kassouf Jim R. Hughes Douglas R. Higgs
Human Molecular Genetics, ddx306, https://doi.org/10.1093/hmg/ddx306
Published: 16 August 2017
Article history Received: 18 July 2017 Revision Received: 18 July 2017
Accepted: 19 July 2017
Source/Fonte: Wired
Abstract
It has been known for over a century that chromatin is not randomly distributed within the nucleus. However, the question of how DNA is folded and the influence of such folding on nuclear processes remain topics of intensive current research. A longstanding, unanswered question is whether nuclear organization is simply a reflection of nuclear processes such as transcription and replication, or whether chromatin is folded by independent mechanisms and this per se encodes function? Evidence is emerging that both may be true. Here, using the α-globin gene cluster as an illustrative model, we provide an overview of the most recent insights into the layers of genome organization across different scales and how this relates to gene activity.
Topic: cell nucleus chromatin dna genes genome globin weight measurement scales
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