The epigenome: the next substrate for engineering
Minhee Park, Albert J. Keung and Ahmad S. KhalilEmail author
Genome Biology 201617:183
DOI: 10.1186/s13059-016-1046-5 © The Author(s). 2016
Published: 31 August 2016
Source/Fonte: National Human Genome Research Institute
Abstract
We are entering an era of epigenome engineering. The precision manipulation of chromatin and epigenetic modifications provides new ways to interrogate their influence on genome and cell function and to harness these changes for applications. We review the design and state of epigenome editing tools, highlighting the unique regulatory properties afforded by these systems.
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