Thirty Years of Multiple Sequence Codes
Edward N. Trifonov a, b,
a Genome Diversity Center, Institute of Evolution, University of Haifa, Haifa 31905, Israel
b Division of Functional Genomics and Proteomics, Faculty of Science, Masaryk University, Brno 61137, Czech Republic
Received 15 September 2010, Accepted 9 December 2010, Available online 7 June 2011
DOI: 10.1016/S1672-0229(11)60001-6
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Open Access funded by Beijing Institute of Genomics, Chinese Academy of Sciences
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Abstract
An overview is presented on the status of studies on multiple codes in genetic sequences. Indirectly, the existence of multiple codes is recognized in the form of several rediscoveries of Second Genetic Code that is different each time. A due credit is given to earlier seminal work related to the codes often neglected in literature. The latest developments in the field of chromatin code are discussed, as well as perspectives of single-base resolution studies of nucleosome positioning, including rotational setting of DNA on the surface of the histone octamers.
Key words genomic code; chromatin code; second genetic code; code interaction; code degeneracy
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