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Adaptive Landscapes in the Age of Synthetic Biology
Xiao Yi Antony M Dean
Molecular Biology and Evolution, msz004,
Published: 17 January 2019
Article history
Received: 14 September 2018 Revision Received: 26 November 2018
Revision Received: 28 December 2018 Accepted: 01 January 2019
Source/Fonte: Nature
Abstract
Adaptive landscapes provide comprehensive overviews of biological phenomena. They reveal, among other things, targets of selection, optimality principles, structural constraints, evolutionary trade-offs and the origins of epistasis. The concept has captivated biologists for nearly a century and yet remains a metaphor. We redefine adaptive landscapes in terms of biological processes rather than descriptive phenomenology. We eschew association studies to focus on the underlying mechanisms that generate emergent properties such as epistasis, dominance, trade-offs and adaptive peaks. We illustrate the utility of landscapes in predicting, among other things, the course of adaptation and the distribution of fitness effects. We abandon aged arguments concerning landscape ruggedness in favor of empirically determining landscape architecture. In so doing, we transform the landscape metaphor into a scientific framework within which causal hypotheses can be tested.
© The Author(s) 2019. Published by Oxford University Press on behalf of the Society for Molecular Biology and Evolution.
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