"Guarda de trânsito" regulador: proteína controla velocidade do emparelhamento dos cromossomos e compartilhamento do DNA

sábado, janeiro 28, 2017

Regulating chromosomal movement by the cochaperone FKB-6 ensures timely pairing and synapsis

Benjamin Alleva, Nathan Balukoff, Amy Peiper, Sarit Smolikove

DOI: 10.1083/jcb.201606126 | Published January 11, 2017


In meiotic prophase I, homologous chromosome pairing is promoted through chromosome movement mediated by nuclear envelope proteins, microtubules, and dynein. After proper homologue pairing has been established, the synaptonemal complex (SC) assembles along the paired homologues, stabilizing their interaction and allowing for crossing over to occur. Previous studies have shown that perturbing chromosome movement leads to pairing defects and SC polycomplex formation. We show that FKB-6 plays a role in SC assembly and is required for timely pairing and proper double-strand break repair kinetics. FKB-6 localizes outside the nucleus, and in its absence, the microtubule network is altered. FKB-6 is required for proper movement of dynein, increasing resting time between movements. Attenuating chromosomal movement in fkb-6 mutants partially restores the defects in synapsis, in agreement with FKB-6 acting by decreasing chromosomal movement. Therefore, we suggest that FKB-6 plays a role in regulating dynein movement by preventing excess chromosome movement, which is essential for proper SC assembly and homologous chromosome pairing.

Submitted: 28 June 2016 Revision received 7 November 2016 Accepted: 29 December 2016

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