Interactive tree of life (iTOL) v3: an online tool for the display and annotation of phylogenetic and other trees
Ivica Letunic1,* and Peer Bork2,3,4
- Author Affiliations
1Biobyte solutions GmbH, Bothestr 142, 69126 Heidelberg, Germany
2European Molecular Biology Laboratory, Meyerhofstrasse 1, 69117 Heidelberg, Germany
3Max Delbrück Centre for Molecular Medicine, 13125 Berlin, Germany
4Department of Bioinformatics, Biocenter, University of Würzburg, 97074 Würzburg, Germany
↵*To whom correspondence should be addressed. Tel: +49 6221 3878534; Email: letunic@biobyte.de
Received February 24, 2016. Revision received April 4, 2016. Accepted April 8, 2016.
Abstract
Interactive Tree Of Life (http://itol.embl.de) is a web-based tool for the display, manipulation and annotation of phylogenetic trees. It is freely available and open to everyone. The current version was completely redesigned and rewritten, utilizing current web technologies for speedy and streamlined processing. Numerous new features were introduced and several new data types are now supported. Trees with up to 100,000 leaves can now be efficiently displayed. Full interactive control over precise positioning of various annotation features and an unlimited number of datasets allow the easy creation of complex tree visualizations. iTOL 3 is the first tool which supports direct visualization of the recently proposed phylogenetic placements format. Finally, iTOL's account system has been redesigned to simplify the management of trees in user-defined workspaces and projects, as it is heavily used and currently handles already more than 500,000 trees from more than 10,000 individual users.
© The Author(s) 2016. Published by Oxford University Press on behalf of Nucleic Acids Research.
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