Hierarchies in eukaryotic genome organization: Insights from polymer theory and simulations
Balaji VS Iyer, Martin Kenward and Gaurav AryaEmail author
BMC Biophysics20114:8
DOI: 10.1186/2046-1682-4-8 © Iyer et al; licensee BioMed Central Ltd. 2011
Received: 7 January 2011Accepted: 15 April 2011Published: 15 April 2011
Source/Fonte: Pearsons Education Inc.
Abstract
Eukaryotic genomes possess an elaborate and dynamic higher-order structure within the limiting confines of the cell nucleus. Knowledge of the physical principles and the molecular machinery that govern the 3D organization of this structure and its regulation are key to understanding the relationship between genome structure and function. Elegant microscopy and chromosome conformation capture techniques supported by analysis based on polymer models are important steps in this direction. Here, we review results from these efforts and provide some additional insights that elucidate the relationship between structure and function at different hierarchical levels of genome organization.
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