Panoramas adaptativos na era da biologia sintética

quarta-feira, janeiro 23, 2019


Adaptive Landscapes in the Age of Synthetic Biology 

Xiao Yi Antony M Dean

Molecular Biology and Evolution, msz004,

Published: 17 January 2019 

Article history

Received: 14 September 2018 Revision Received: 26 November 2018

Revision Received: 28 December 2018 Accepted: 01 January 2019

Image result for adaptive landscapes biology
Source/Fonte: Nature


Adaptive landscapes provide comprehensive overviews of biological phenomena. They reveal, among other things, targets of selection, optimality principles, structural constraints, evolutionary trade-offs and the origins of epistasis. The concept has captivated biologists for nearly a century and yet remains a metaphor. We redefine adaptive landscapes in terms of biological processes rather than descriptive phenomenology. We eschew association studies to focus on the underlying mechanisms that generate emergent properties such as epistasis, dominance, trade-offs and adaptive peaks. We illustrate the utility of landscapes in predicting, among other things, the course of adaptation and the distribution of fitness effects. We abandon aged arguments concerning landscape ruggedness in favor of empirically determining landscape architecture. In so doing, we transform the landscape metaphor into a scientific framework within which causal hypotheses can be tested.

© The Author(s) 2019. Published by Oxford University Press on behalf of the Society for Molecular Biology and Evolution.

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (, which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact