Annu. Rev. Biochem. 2017. 86:685–714
First published as a Review in Advance on March 15, 2017
The Annual Review of Biochemistry is online at biochem.annualreviews.org
Mitochondrial Machineries for Protein Import and Assembly
Nils Wiedemann and Nikolaus Pfanner
Institute of Biochemistry and Molecular Biology, ZBMZ, Faculty of Medicine, and BIOSS
Centre for Biological Signaling Studies, University of Freiburg, 79104 Freiburg, Germany;
email:nils.wiedemann@biochemie.uni-freiburg.de, nikolaus.pfanner@biochemie.uni-freiburg.de
Keywords
Abstract
Mitochondria are essential organelles with numerous functions in cellular metabolism and homeostasis. Most of the >1,000 different mitochondrial proteins are synthesized as precursors in the cytosol and are imported into mitochondria by five transport pathways. The protein import machineries of the mitochondrial membranes and aqueous compartments reveal a remarkable variability of mechanisms for protein recognition, translocation, and sorting. The protein translocases do not operate as separate entities but are connected to each other and to machineries with functions in energetics, membrane organization, and quality control. Here, we discuss the versatility translocases into a large network that controls organelle biogenesis, function, and dynamics.
Copyright © 2017 Wiedemann & Pfanner.
This work is licensed under a Creative Commons Attribution 4.0 International License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. See credit lines of images or other third party material in this article for license information.
FREE PDF GRATIS: Annu Rev Biochem
