Regulação gênica: um interruptor transcricional controla a meiose - mero acaso, fortuita necessidade ou design inteligente?

terça-feira, dezembro 12, 2017

Gene Regulation: A transcriptional switch controls meiosis

A Elizabeth Hildreth Karen M Arndt Is a corresponding author

University of Pittsburgh, United States

INSIGHT Oct 24, 2017

Transcriptional switching between two mRNA transcripts regulates the assembly of the kinetochore during meiosis.


A key protein involved in the segregation of meiotic chromosomes is produced 'just in time' by the regulated expression of two mRNA isoforms.




Two papers in eLife, Elçin Ünal, Folkert van Werven and colleagues at the University of California at Berkeley and the Francis Crick Institute report a transcriptional switch that controls the timing of a critical event in the development of the yeast Saccharomyces cerevisiae (Chen et al., 2017; Chia et al., 2017).