Design em 4D - Projeto Nucleoma - mais problemas para a teoria da evolução de Darwin???

sexta-feira, setembro 22, 2017

The 4D nucleome project

Job Dekker, Andrew S. Belmont, Mitchell Guttman, Victor O. Leshyk, John T. Lis, Stavros Lomvardas, Leonid A. Mirny, Clodagh C. O’Shea, Peter J. Park, Bing Ren, Joan C. Ritland Politz, Jay Shendure, Sheng Zhong & the 4D Nucleome Network

Affiliations Contributions Corresponding author

Nature 549, 219–226 (14 September 2017) doi:10.1038/nature23884 

Received 27 January 2017 Accepted 27 July 2017 Published online 13 September 2017

The 4D Nucleome project.


The 4D Nucleome Network aims to develop and apply approaches to map the structure and dynamics of the human and mouse genomes in space and time with the goal of gaining deeper mechanistic insights into how the nucleus is organized and functions. The project will develop and benchmark experimental and computational approaches for measuring genome conformation and nuclear organization, and investigate how these contribute to gene regulation and other genome functions. Validated experimental technologies will be combined with biophysical approaches to generate quantitative models of spatial genome organization in different biological states, both in cell populations and in single cells.

Subject terms: Epigenomics Gene regulation