Quebrando o epitranscriptoma

quinta-feira, março 30, 2017

Cracking the epitranscriptome

Schraga Schwartz

- Author Affiliations

Department of Molecular Genetics, Weizmann Institute, Rehovot 76100, Israel

Corresponding author: schwartz@weizmann.ac.il

Source/Fonte: Nature


Over 100 distinct chemical modifications can be catalyzed on RNA post-synthesis, potentially serving as a post-transcriptional regulatory layer of gene expression. This review focuses on recent advances, knowledge gaps, and challenges pertaining to N6-methyladenosine (m6A), an abundant modification of mRNA for which substantial progress has been made in recent years. The discussed aspects are also very relevant for a wide range of additional modifications on mRNA collectively coined the epitranscriptome.

Keywords N6-methyladenosine epitranscriptome review


Article and publication date are at

© 2016 Schwartz; Published by Cold Spring Harbor Laboratory Press for the RNA Society

This article is distributed exclusively by the RNA Society for the first 12 months after the full-issue publication date (see http://rnajournal.cshlp.org/site/misc/terms.xhtml). After 12 months, it is available under a Creative Commons License (Attribution-NonCommercial 4.0 International), as described at http://creativecommons.org/licenses/by-nc/4.0/.