O epigenoma: o próximo substrato de engenharia epigenômica

quinta-feira, setembro 29, 2016

The epigenome: the next substrate for engineering

Minhee Park, Albert J. Keung and Ahmad S. KhalilEmail author

Genome Biology 201617:183

DOI: 10.1186/s13059-016-1046-5 © The Author(s). 2016

Published: 31 August 2016


We are entering an era of epigenome engineering. The precision manipulation of chromatin and epigenetic modifications provides new ways to interrogate their influence on genome and cell function and to harness these changes for applications. We review the design and state of epigenome editing tools, highlighting the unique regulatory properties afforded by these systems.

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