iTOL, a Árvore da Vida interativa

terça-feira, julho 05, 2016

Interactive tree of life (iTOL) v3: an online tool for the display and annotation of phylogenetic and other trees

Ivica Letunic1,* and Peer Bork2,3,4

- Author Affiliations

1Biobyte solutions GmbH, Bothestr 142, 69126 Heidelberg, Germany

2European Molecular Biology Laboratory, Meyerhofstrasse 1, 69117 Heidelberg, Germany

3Max Delbrück Centre for Molecular Medicine, 13125 Berlin, Germany

4Department of Bioinformatics, Biocenter, University of Würzburg, 97074 Würzburg, Germany

↵*To whom correspondence should be addressed. Tel: +49 6221 3878534; Email:

Received February 24, 2016. Revision received April 4, 2016. Accepted April 8, 2016.


Interactive Tree Of Life ( is a web-based tool for the display, manipulation and annotation of phylogenetic trees. It is freely available and open to everyone. The current version was completely redesigned and rewritten, utilizing current web technologies for speedy and streamlined processing. Numerous new features were introduced and several new data types are now supported. Trees with up to 100,000 leaves can now be efficiently displayed. Full interactive control over precise positioning of various annotation features and an unlimited number of datasets allow the easy creation of complex tree visualizations. iTOL 3 is the first tool which supports direct visualization of the recently proposed phylogenetic placements format. Finally, iTOL's account system has been redesigned to simplify the management of trees in user-defined workspaces and projects, as it is heavily used and currently handles already more than 500,000 trees from more than 10,000 individual users.

© The Author(s) 2016. Published by Oxford University Press on behalf of Nucleic Acids Research.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (, which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact

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