Descoberto o elo entre a estrutura e função das proteínas: mero acaso, fortuita necessidade ou design inteligente?

quinta-feira, maio 19, 2016

The early history and emergence of molecular functions and modular scale-free network behavior

M. Fayez Aziz, Kelsey Caetano-Anollés & Gustavo Caetano-Anollés

Scientific Reports 6, Article number: 25058 (2016)

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Molecular evolution Power law Protein function predictions

Received: 01 October 2015 Accepted: 08 April 2016 Published online: 28 April 2016


The formation of protein structural domains requires that biochemical functions, defined by conserved amino acid sequence motifs, be embedded into a structural scaffold. Here we trace domain history onto a bipartite network of elementary functional loop sequences and domain structures defined at the fold superfamily level of SCOP classification. The resulting ‘elementary functionome’ network and its loop motif and structural domain graph projections create evolutionary ‘waterfalls’ describing the emergence of primordial functions. Waterfalls reveal how ancient loops are shared by domain structures in two initial waves of functional innovation that involve founder ‘p-loop’ and ‘winged helix’ domain structures. They also uncover a dynamics of modular motif embedding in domain structures that is ongoing, which transfers ‘preferential’ cooption properties of ancient loops to emerging domains. Remarkably, we find that the emergence of molecular functions induces hierarchical modularity and power law behavior in network evolution as the network of motifs and structures expand metabolic pathways and translation.

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