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quarta-feira, maio 11, 2016

High-performance web services for querying gene and variant annotation

Jiwen Xin†, Adam Mark†, Cyrus Afrasiabi†, Ginger Tsueng, Moritz Juchler, Nikhil Gopal, Gregory S. Stupp, Timothy E. Putman, Benjamin J. Ainscough, Obi L. Griffith, Ali Torkamani, Patricia L. Whetzel, Christopher J. Mungall, Sean D. Mooney, Andrew I. SuEmail author and Chunlei WuEmail author

†Contributed equally

Genome Biology201617:91

DOI: 10.1186/s13059-016-0953-9 © Xin et al. 2016

Received: 7 January 2016 Accepted: 14 April 2016 Published: 6 May 2016


Efficient tools for data management and integration are essential for many aspects of high-throughput biology. In particular, annotations of genes and human genetic variants are commonly used but highly fragmented across many resources. Here, we describe MyGene.info and MyVariant.info, high-performance web services for querying gene and variant annotation information. These web services are currently accessed more than three million times permonth. They also demonstrate a generalizable cloud-based model for organizing and querying biological annotation information. MyGene.info and MyVariant.info are provided as high-performance web services, accessible at http://​mygene.​info and http://​myvariant.​info. Both are offered free of charge to the research community.

Keywords Annotation Gene Variant API Cloud Repository Database

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