Reducionismo e complexidade em biologia molecular: Chamem a turma do Design Inteligente!!!

segunda-feira, outubro 21, 2013

Reductionism and complexity in molecular biology

Marc H.V. Van Regenmortel

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Scientists now have the tools to unravel biological complexity and overcome the limitations of reductionism

The reductionist method of dissecting biological systems into their constituent parts has been effective in explaining the chemical basis of numerous living processes. However, many biologists now realize that this approach has reached its limit. Biological systems are extremely complex and have emergent properties that cannot be explained, or even predicted, by studying their individual parts. The reductionist approach—although successful in the early days of molecular biology—underestimates this complexity and therefore has an increasingly detrimental influence on many areas of biomedical research, including drug discovery and vaccine development.

The claim made by Francis Crick (1966) that “The ultimate aim of the modern movement in biology is to explain all biology in terms of physics and chemistry” epitomizes the reductionist mindset that has pervaded molecular biology for half a century. The theory is that because biological systems are composed solely of atoms and molecules, without the influence of 'alien' or 'spiritual' forces, it should be possible to explain them using the physicochemical properties of their individual components, down to the atomic level. The most extreme manifestation of the reductionist view is the belief that is held by some neuroscientists that consciousness and mental states can be reduced to chemical reactions that occur in the brain (Bickle, 2003; Van Regenmortel, 2004).

Reductionists analyse a larger system by breaking it down into pieces and determining the connections between the parts. They assume that the isolated molecules and their structure have sufficient explanatory power to provide an understanding of the whole system. As the value of methodo-logical reductionism hasbeen particularly evident in molecular biology, it might seem odd that, in recent years, biologists have become increasingly critical of the idea that biological systems can be fully explained using physics and chemistry. Their situation is similar to that of an art student asking about the significance of Michelangelo's David and being told that it is just a piece of marble hewn into a statue in 1504. This is certainly true, but it evades pertinent questions about the anatomy of the statue, its creation at the beginning of the Florentine Renaissance, its significance in European art history, or even the scars on its left arm that were plastered after it was broken in three places during the anti-Medici revolt of 1527. In an analogous way, the biology, development, physiology, behaviour or fate of a human being cannot be adequately explained along reductionist lines that consider only chemical composition. Anti-reductionists therefore regard biology as an autonomous discipline that requires its own vocabulary and concepts that are not found in chemistry and physics. Both sides have discussed their standpoints at several recent international meetings (Bock & Goode, 1998; Van Regenmortel & Hull, 2002; Van Regenmortel, 2004) and the main disagreement between the protagonists is about what constitutes a good scientific explanation.