A função dos íntrons

segunda-feira, fevereiro 25, 2013

Front Genet. 2012; 3: 55.

Published online 2012 April 13. Prepublished online 2012 March 5. doi:  10.3389/fgene.2012.00055

The Function of Introns

Michal Chorev1,2 and Liran Carmel1,*


The intron–exon architecture of many eukaryotic genes raises the intriguing question of whether this unique organization serves any function, or is it simply a result of the spread of functionless introns in eukaryotic genomes. In this review, we show that introns in contemporary species fulfill a broad spectrum of functions, and are involved in virtually every step of mRNA processing. We propose that this great diversity of intronic functions supports the notion that introns were indeed selfish elements in early eukaryotes, but then independently gained numerous functions in different eukaryotic lineages. We suggest a novel criterion of evolutionary conservation, dubbed intron positional conservation, which can identify functional introns.

Keywords: intron function, gene architecture, intron–exon structure, intron positional conservation, expression regulation, non-coding RNAs, exon-junction complex, splicing

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