Logística celular de transporte de cargas: mero acaso, fortuita necessidade ou design inteligente???

segunda-feira, outubro 03, 2011

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An EMBO Journal special on cellular logistics - moving 

This Focus issue comprises eight reviews united by a common interest in understanding how and why cells move cargo around. Active transport mechanisms transcend compartment boundaries within cells and permit communication between them. Recent technological advances have opened our eyes to the dynamic nature of such trafficking processes. The examples discussed here by leaders in the field showcase the diversity in transport systems and cargoes, and the complexity of organising these in space and time. Nevertheless, recurrent themes emerge, highlighting universal principles required to coordinate the remarkable logistics of cellular transport.



The five ‘W’s of transport FREE

Isabel Arnold and Katherine Brown
The EMBO Journal (2011), 303455 - 3456,doi:10.1038/emboj.2011.275

Focus Reviews

Ran-dependent nuclear export mediators: a structural perspective FREE

Diverse import and export complexes mediate transport between the nucleus and cytoplasm. The contribution of structural data to our understanding of the molecular basis underlying specificity and directionality of transport is discussed here.
Thomas Güttler and Dirk Görlich
The EMBO Journal (2011), 30 , 3457 - 3474 , doi:10.1038/emboj.2011.287

Protein export at the ER: loading big collagens into COPII carriers FREE

The secretory pathway needs to accommodate many different types and sizes of cargo. As detailed in this review, the molecules and mechanisms that package large cargoes such as collagen for ER exit have recently been uncovered.
Vivek Malhotra and Patrik Erlmann
The EMBO Journal (2011), 303475 - 3480,doi:10.1038/emboj.2011.255