Os mundos RNA em contexto

quinta-feira, fevereiro 17, 2011

Cold Spring Harbor Perspectives in Biology

The RNA Worlds in Context

+Author Affiliations

Department of Chemistry and Biochemistry, Howard Hughes Medical Institute, University of Colorado, Boulder, Colorado 80309-0215
Correspondence: thomas.cech@colorado.edu


There are two RNA worlds. The first is the primordial RNA world, a hypothetical era when RNA served as both information and function, both genotype and phenotype. The second RNA world is that of today's biological systems, where RNA plays active roles in catalyzing biochemical reactions, in translating mRNA into proteins, in regulating gene expression, and in the constant battle between infectious agents trying to subvert host defense systems and host cells protecting themselves from infection. This second RNA world is not at all hypothetical, and although we do not have all the answers about how it works, we have the tools to continue our interrogation of this world and refine our understanding. The fun comes when we try to use our secure knowledge of the modern RNA world to infer what the primordial RNA world might have looked like.

Copyright © 2011 Cold Spring Harbor Laboratory Press; all rights reserved