Resposta do DNA ao dano

quinta-feira, outubro 28, 2010

DNA Damage Response

Giuseppina Giglia-Mari1,2,3, Angelika Zotter1,4 and Wim Vermeulen1

-Author Affiliations

1Department of Genetics, Erasmus University Medical Center, Dr Molewaterplein 50, 3015 GE Rotterdam, The Netherlands
2Department of Cancer Biology, Institute of Pharmacology and Structural Biology, CNRS, 205 route de Narbonne, 31077 Toulouse, France
3Université de Toulouse Paul Sabatier, 31000, Toulouse, France
4Core Research Laboratory, Istituto Toscano Tumori, Villa delle Rose, Via Cosimo il Vecchio 2, 50139 Firenze, Italy



Structural changes to DNA severely affect its functions, such as replication and transcription, and play a major role in age-related diseases and cancer. A complicated and entangled network of DNA damage response (DDR) mechanisms, including multiple DNA repair pathways, damage tolerance processes, and cell-cycle checkpoints safeguard genomic integrity. Like transcription and replication, DDR is a chromatin-associated process that is generally tightly controlled in time and space. As DNA damage can occur at any time on any genomic location, a specialized spatio-temporal orchestration of this defense apparatus is required.

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