Territórios cromossômicos

quinta-feira, fevereiro 25, 2010

Chromosome Territories

Thomas Cremer1,2 and
Marion Cremer1

-Author Affiliations

1Biozentrum, Department of Biology II (Chair of Anthropology and Human Genetics), Ludwig-Maximilians-University, Grosshadernerstrasse 2, 82152 Martinsried, Germany

2Munich Center for Integrated Protein Sciences (CIPSM), 81377 Munich, Germany



Chromosome territories (CTs) constitute a major feature of nuclear architecture. In a brief statement, the possible contribution of nuclear architecture studies to the field of epigenomics is considered, followed by a historical account of the CT concept and the final compelling experimental evidence of a territorial organization of chromosomes in all eukaryotes studied to date. Present knowledge of nonrandom CT arrangements, of the internal CT architecture, and of structural interactions with other CTs is provided as well as the dynamics of CT arrangements during cell cycle and postmitotic terminal differentiation. The article concludes with a discussion of open questions and new experimental strategies to answer them.
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