Evoluindo a estabilidade da proteína através da seleção genética

sábado, janeiro 16, 2010

Evolving Protein Stability through Genetic Selection

R. Luke Wiseman23Go To Corresponding Author  and Jeffery W. Kelly13Go To Corresponding Author 
1 Department of Chemistry, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
2 Department of Chemical Physiology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
3 Department of Molecular and Experimental Medicine, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
Summary
In this issue of Molecular CellFoit et al. (2009) probe cellular protein folding using a split β-lactamase approach for evolving protein stability in the absence of any requirement for function.

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