A natureza dos pontos de controle do ciclo celular: fatos e falácias

The nature of cell-cycle checkpoints: facts and fallacies

Alexey Khodjakov and Conly L Rieder

Wadsworth Center, PO Box 509, Albany, NY 12201-0509, USA

author email corresponding author email

Journal of Biology 2009, 8:88doi:10.1186/jbiol195

The electronic version of this article is the complete one and can be found online at: http://jbiol.com/content/8/10/88

Published: 16 November 2009

© 2009 BioMed Central Ltd


Abstract

The concept of checkpoint controls revolutionized our understanding of the cell cycle. Here we revisit the defining features of checkpoints and argue that failure to properly appreciate the concept is leading to misinterpretation of experimental results. We illustrate, using the mitotic checkpoint, problems that can arise from a failure to respect strict definitions and precise terminology.

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