Reconstrução de genomas ancestrais

Breakpoint graphs and ancestral genome reconstructions
Max A. Alekseyev and Pavel A. Pevzner,1
+Author Affiliations

Department of Computer Science and Engineering, University of California at San Diego, La Jolla, California 92093-0404, USA
Abstract

Recently completed whole-genome sequencing projects marked the transition from gene-based phylogenetic studies to phylogenomics analysis of entire genomes. We developed an algorithm MGRA for reconstructing ancestral genomes and used it to study the rearrangement history of seven mammalian genomes: human, chimpanzee, macaque, mouse, rat, dog, and opossum. MGRA relies on the notion of the multiple breakpoint graphs to overcome some limitations of the existing approaches to ancestral genome reconstructions. MGRA also generates the rearrangement-based characters guiding the phylogenetic tree reconstruction when the phylogeny is unknown.

Footnotes

↵1 Corresponding author.

↵E-mail ppevzner@cs.ucsd.edu; fax (858) 534-7029.

[Supplemental material is available online at www.genome.org.]

Article published online before print. Article and publication date are at http://www.genome.org/cgi/doi/10.1101/gr.082784.108.

Received June 30, 2008.
Accepted January 22, 2009.

Copyright © 2009 by Cold Spring Harbor Laboratory Press

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